Impact of High Salt Independent of Blood Pressure on PRMT/ADMA/DDAH Pathway in the Aorta of Dahl Salt-Sensitive Rats

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Impact of High Salt Independent of Blood Pressure on PRMT/ADMA/DDAH Pathway in the Aorta of Dahl Salt-Sensitive Rats

Endothelial dysfunction participates in the development and progression of salt-sensitive hypertension. Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase (NOS). The objectives of this study were to investigate the impact of a high salt diet on the PRMT/ADMA/DDAH (protein arginine methyltransferases; dimethylarginine dimethylaminohydrolase) pathway in Dahl sa...

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Inconsistent blood pressure phenotype in female Dahl salt-sensitive rats.

TO THE EDITOR: The recent article “20-HETE and CYP4A2 -hydroxylase contribute to the elevated blood pressure in hyperandrogenemic female rats” by Dalmasso et al. (3) brings attention to phenotypic irregularities observed in female Dahl salt-sensitive (SS) rats. This hypertensive rodent model is frequently utilized to assess both the cardiovascular effects of a high-salt diet and the impact of s...

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ژورنال

عنوان ژورنال: International Journal of Molecular Sciences

سال: 2013

ISSN: 1422-0067

DOI: 10.3390/ijms14048062